View details for DOI 10.1186/s12883-019-1552-7. Profile von Personen mit dem Namen Michael Stanfor anzeigen. View details for DOI 10.1016/j.cllc.2013.12.009. Non-Contrast T2-Weighted MR Sequences for Long Term Monitoring of Asymptomatic Convexity Meningiomas. Advances in 3-dimensional (3D) printing technology permit the rapid creation of detailed anatomical models. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials. Conclusion MRI measurements of susceptibility, R2*, and R2' (R2* - R2) obtained after ferumoxytol administration correlate with iron-containing macrophage concentration, and this shows their potential as quantitative imaging markers of macrophages in malignant gliomas. Mean susceptibility (in parts per million [ppm]) and R2* (in inverse seconds [sec-1]) values of the dentate (case participants: 0.06 ppm 0.04 and 23.87 sec-1 4.13; control participants: 0.02 ppm 0.03 and 21.7 sec-1 5.26), substantia nigrae (case participants: 0.08 ppm 0.06 and 27.46 sec-1 5.58; control participants: 0.04 ppm 0.05 and 24.96 sec-1 5.3), globus pallidi (case participants: 0.14 ppm 0.05 and 30.75 sec-1 5.14; control participants: 0.08 ppm 0.07 and 28.82 sec-1 6.62), putamina (case participants: 0.03 ppm 0.02 and 20.63 sec-1 2.44; control participants: 0.02 ppm 0.02 and 19.65 sec-1 3.6), caudate (case participants: -0.1 ppm 0.04 and 18.21 sec-1 3.1; control participants: -0.06 ppm 0.05 and 18.83 sec-1 3.32), and thalami (case participants: 0 ppm 0.03 and 16.49 sec-1 3.6; control participants: 0.02 ppm 0.02 and 18.38 sec-1 2.09) did not differ between groups (susceptibility, P = .21; R2*, P = .24). Our purpose is to describe the association between demyelinating lesions and venous anomalies, as only one case of TD associated with a DVA has been published in the literature. IRR increased most among non-CNS specialists (+58%, p<0.001). Overall, the inter-rater agreement between two readers for lesion count on pTOF was classified as almost perfect (=0.98, 96% CI 0.8-1.0).In this study, TOF-MRA simultaneously generated in addition to SWI from 3D MR-GRE can serve as a diagnostic adjunct, particularly for proximal vessel disease and when conventional TOF-MRA images are absent. Iv, M., Telischak, N., Feng, D., Holdsworth, S. J., Yeom, K. W., Daldrup-Link, H. E. Development and Validation of Operator Independent Measurements of Optic Nerve Sheath Cerebral Spinal Fluid Volume from MRI. In this article, we report a case of critical illness-associated cerebral microbleeds identified on MRI in a patient with severe COVID-19 infection and discuss the potential etiologies of these neuroimaging findings. Statistical analyses were performed using generalized linear models.No significant difference was found between CSF metal levels across diagnostic groups. However, major challenges remain for methodologic developments to optimize feature extraction and provide rapid information flow in clinical settings. Future multicenter studies could further investigate the efficacy of Fe-MRI as a noninvasive alternative to DSA for monitoring AVMs in children. Can diffusion- and perfusion-weighted imaging alone accurately triage anterior circulation acute ischemic stroke patients to endovascular therapy? Iv, M., Ng, N. N., Nair, S., Zhang, Y., Lavezo, J., Cheshier, S. H., Holdsworth, S. J., Moseley, M. E., Rosenberg, J., Grant, G. A., Yeom, K. W. Deep Learning Enables Automatic Detection and Segmentation of Brain Metastases on Multisequence MRI. We further discuss machine-learning challenges and data opportunities to advance radiomic studies. Clinical and Arterial Spin Labeling Brain MRI Features of Transitional Venous Anomalies. Materials and Methods In this prospective study, adults with high-grade gliomas were enrolled between July 2015 and July 2017. View details for DOI 10.3389/fneur.2020.00270, View details for PubMedCentralID PMC7174761. MRI and histopathology support the mechanism of action to inhibit post-irradiation tumor revascularization.Infusion of the CXCR4 inhibitor plerixafor was well tolerated as an adjunct to standard chemo-irradiation in newly diagnosed GBM patients and improves local control of tumor recurrences. Seventy-three patients (33%) underwent endovascular AIS treatment. Panesar, S. S., Magnetta, M., Mukherjee, D., Abhinav, K., Branstetter, B. F., Gardner, P. A., Iv, M., Fernandez-Miranda, J. C. Khalaf, A., Iv, M., Fullerton, H., Wintermark, M. Conus Medullaris Dural Arteriovenous Fistula Arising From the Artery of the Filum Terminale: 2-Dimensional Operative Video. Patients of the angiogenic subgroups pooled from both cohorts, who had chemotherapy information available, had significantly longer survival when treated with antiangiogenic therapy (log-rank P=.022).Our findings suggest that an angiogenic subtype of GBM patients may benefit from antiangiogenic therapy with improved overall survival. This supplement sketches how a reductive form of analysis emerged in Descartes’s development of analytic geometry, and elaborates onthe way in which decompositional conceptions of analysis came to the fore in the early modern period, as outlined in §4of the main document. The mean number of ferumoxytol administrations was 2 1 (range, one to four). View Records. Methods: In an animal care and use committee-approved prospective case-control study, ten Gttingen minipigs received either intravenous ferumoxytol injections at a dose of 5 mg Fe/kg (n=4) or remained untreated (n=6). Imaging Manifestations of Primary and Disseminated Coccidioidomycosis, Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors, Congenital Brain Malformations in the Neonatal and Early Infancy Period, Imaging Neck Masses in the Neonate and Young Infant, Intensity-Corrected Dual-Echo Echo-Planar Imaging (DE-EPI) for Improved Pediatric Brain Diffusion Imaging. After a self-directed training module, participating physicians completed the "post-training" phase and relabeled the 30 cases using the 4 following labels: LR, DR, cLMD, nLMD.Inter-rater reliability (IRR) increased 34% after training (Fleiss' Kappa K=0.41 to K=0.55, p<0.001). An involved vessel's mean diameter was 1.1028 0.2634 mm. Select any poster below to play the movie, totally free! Prussian blue stains of the same brain regions, scored according to a semiquantitative score, were not significantly different either between the ferumoxytol exposed group and unexposed controls (p>0.05). We report on the accuracy of electrode placement under robotic assistance planning utilizing a novel high-resolution magnetic resonance imaging (MRI)-based imaging modality.Sixteen pediatric patients between February 2014 and October 2017 underwent SEEG exploration for epileptogenic zone localization. They also recorded the presence or absence of tumor blush on DSA in each case. Nine to twelve months later, pigs were sacrificed and the brains of all pigs underwent ex vivo MRI at 7T with T2 and T2*-weighted sequences. Deep Learning for Pediatric Posterior Fossa Tumor Detection and Classification: A Multi-Institutional Study. Echo1 [TE = 45ms] and Echo2 [TE = 86ms] were corrected for signal intensity variation across the images by exploiting the images equivalent coil-sensitivity and susceptibility-induced modulations. Kalnins, A., Penta, M., El-Sawy, T., Liao, Y. J., Fischbein, N., Iv, M. Non-Contrast T2-Weighted MR Sequences for Long Term Monitoring of Asymptomatic Convexity Meningiomas. Michael has 3 jobs listed on their profile. As such, it may further delineate functional and dysfunctional neuronal networks, guide stroke interventions, and improve prognosis and monitoring of patient outcomes. Contrast-enhanced magnetic resonance imaging (MRI) is the traditional imaging method for the evaluation of brain metastases, as it provides information about lesion size, morphology, and macroscopic properties. Theruvath, A. J., Aghighi, M., Iv, M., Nejadnik, H., Lavezo, J., Pisani, L. J., Daldrup-Link, H. E. Utilization of Novel High-Resolution, MRI-Based Vascular Imaging Modality for Preoperative Stereoelectroencephalography Planning in Children: A Technical Note. Stanford Libraries' official online search tool for books, media, journals, databases, government documents and more. View details for DOI 10.1148/rg.2017160035, View details for Web of Science ID 000397205200021. Measurements were assessed by linear regression analyses: a between-group comparison of ferumoxytol-exposed and unexposed participants and a within-group (subgroup) comparison before and after exposure. Abhinav, K., Nielsen, T. H., Singh, R., Weng, Y., Han, S. S., Iv, M., Steinberg, G. K. Altered cerebral perfusion in children with Langerhans cell histiocytosis after chemotherapy. On average, patients received two surveillance DSA studies over the study period, which on average equated to a TDAP of 117.2 Gycm2 (95% CI 77.2-157.4 Gycm2) and an effective dose of 7.8 mSv (95% CI 4.4-8.8 mSv).Fe-MRI performed similarly to DSA for the surveillance of residual AVMs. Unsupervised consensus clustering was performed to identify robust clusters of GBM in each cohort. Radiomics in Brain Tumor: Image Assessment, Quantitative Feature Descriptors, and Machine-Learning Approaches. The sensitivity and specificity for detecting residual AVMs using Fe-SPGR were 100% and 100%, and using ASL they were 72% and 100%, respectively. For the subgroup, the mean interval between the first and last ferumoxytol administration was 14 months 8 (range, 1-25 months). 1701 Page Mill Road. Receiver operating characteristic analysis revealed superior performance of the double 10-fold cross-validation model for predicting sonic hedgehog, group 3, and group 4 tumors when using combined T1- and T2-weighted images (area under the curve = 0.79, 0.70, and 0.83, respectively). Taylor, J. L., Hambro, B. C., Strossman, N. D., Bhatt, P., Hernandez, B., Ashford, J. W., Cheng, J. J., Iv, M., Adamson, M. M., Lazzeroni, L. C., McNerney, M. W. Malignant optic glioma masked by suspected optic neuritis and central retinal vein occlusion. We identified five key drivers: (a) streamlined protocols, (b) consistent patient monitoring, (c) clear visual slides and audio, (d) improved patient understanding, and (e) minimized patient motion. Percent tumor growth was measured by comparing cross-sectional area at maximum tumor diameter from the earliest and most recent scans. Acute ischemic stroke (AIS) patients who benefit from endovascular treatment have a large vessel occlusion (LVO), small core infarction, and salvageable brain. Given concern regarding GBCA deposition, we sought to determine if non-contrast MRs in patients with asymptomatic meningiomas were equivalent to GBCA-enhanced MRs in surveillance monitoring.This IRB-approved retrospective chart review included 106 MR sequences from 18 patients. A gadolinium-enhanced 3D T1-weighted spoiled gradient recalled echo sequence with minimum echo time and repetition time was applied for background parenchymal suppression and vascular enhancement. Similar significance results were obtained with linear mixed models. Brain MRI in these patients have revealed various findings including ischemia, hemorrhage, inflammation, and demyelination. All cases were adenocarcinoma; 60% of patients had a known or suspected driver mutation. There were no significant differences in R2* values of the different brain regions in the ferumoxytol exposed group compared to controls (p>0.05). Of these, 121 underwent both perfusion modalities, 15 only PWI, and 127 only ASL. Our study indicates that these lesions are usually incidentally detected and have a lower risk of hemorrhage than AVMs. Shams, M., Martola, J., Charidimou, A., Granberg, T., Ferreira, D., Westman, E., Wintermark, M., Iv, M., Larvie, M., Kristoffersen Wiberg, M., Kaijser, M., Forsgard, N., Zetterberg, H., Wahlund, L. O., Shams, S. Simultaneous time of flight-MRA and T2* imaging for cerebrovascular MRI. However, recent studies of the effects of repetitive transcranial magnetic stimulation (rTMS) in AD have demonstrated improvements in cognitive function. View details for DOI 10.1007/s00234-020-02499-5, Conventional single-shot FSE commonly used for fast MRI may be suboptimal for brain evaluation due to poor image contrast, SNR, or image blurring. View details for DOI 10.1016/j.clinimag.2020.08.029. Radiologists reported overall high diagnostic confidence using Fe-SPGR. View details for DOI 10.1016/j.ijrobp.2019.10.002. The process of verbally reporting or manually retyping numeric data generated at dual-energy x-ray absorptiometry (DXA) involves numerous pitfalls. Access your health information from any device with MyHealth. He currently serves as the Director of Brain Tumor Imaging at the Stanford Brain Tumor Center. RSNA, 2020. Two neuroradiologists independently reviewed Echo1 and Echo2 and their intensity-corrected variants (cEcho1 and cEcho2) on a 7-point Likert scale, with grading on lesion conspicuity diagnostic confidence. Multivariable regression analysis was used for statistical analysis.A total of 18 patients [brainstem (15) and thalamus/basal ganglia (3); median follow-up: 270 d] were identified over 2 yr. Although biopsy is often required for definitive diagnosis, imaging can provide useful information. Elizabeth Tong MD. Quantification of Macrophages in High-Grade Gliomas by Using Ferumoxytol-enhanced MRI: A Pilot Study. Each participant was administered intravenous ferumoxytol (5 mg/kg) and underwent 3.0-T MRI 24 hours later. In previous clinical trials, antiangiogenic therapies such as bevacizumab did not show efficacy in patients with newly diagnosed glioblastoma (GBM). In this study, we investigated, if intravenously administered ferumoxytol nanoparticles are deposited in porcine brains. Lamsam, L., Quon, J., Fischbein, N., Iv, M., Dodd, R., Ratliff, J. View details for DOI 10.5853/jos.2016.00563. Economic History. Yoon, B. C., Saad, A. F., Rezaii, P., Wintermark, M., Zaharchuk, G., Iv, M. Radiomics in Brain Tumor: Image Assessment, Quantitative Feature Descriptors, and Machine-Learning Approaches. The resulting features can be used to inform imaging diagnosis, prognosis, and therapy response in oncology. Jabarkheel, R., Tong, E., Lee, E. H., Cullen, T. M., Yousaf, U., Loening, A. M., Taviani, V., Iv, M., Grant, G. A., Holdsworth, S. J., Vasanawala, S. S., Yeom, K. W. A PHASE 1 STUDY OF BPM31510 PLUS VITAMIN K IN SUBJECTS WITH HIGH-GRADE GLIOMA THAT HAS RECURRED ON A BEVACIZUMAB-CONTAINING REGIMEN. Phase I study of BPM31510 and vitamin K in patients with high grade glioma recurrent after a bevacizumab-containing regimen. Iv, M., Yoon, B. C., Heit, J. J., Fischbein, N., Wintermark, M. Quantification of Macrophages in High-Grade Gliomas by Using Ferumoxytol-enhanced MRI: A Pilot Study. The mean diameter for an involved vessel was 1.0236 0.0928 mm, and superficial vessels were involved in 20.13%. Kroll, H., Zaharchuk, G., Christen, T., Heit, J. J., Iv, M. Reducing Functional MR Imaging Acquisition Times by Optimizing Workflow. ASL-MRI may be a useful tool to identify TVAs and guide further management of patients with TVAs. This may be a result of the heterogeneity of GBM, which has a variety of imaging-based phenotypes and gene expression patterns. Significant positive correlations were found between susceptibility, R2*, and R2' and the number of high-power fields with CD163-positive (r range, 0.64-0.71; P < .01) and CD68-positive (r range, 0.55-0.57; P value range, .01-.02) iron-containing macrophages. Arterial Spin-Labeling MRI Identifies Hypervascular Meningiomas. Two neuroradiologists blinded to the DSA results independently assessed Fe-enhanced T1-weighted spoiled gradient recalled acquisition in steady state (Fe-SPGR) scans and, if available, arterial spin labeling (ASL) perfusion scans for residual or recurrent AVMs. In conclusion, assessment of left ventricular EF from CT coronary data using the new analysis software is rapid and easy. In the "pre-training" phase, physicians labeled cases using 3 patterns of recurrence commonly reported in prospective studies: local recurrence (LR), distant parenchymal recurrence (DR), and LMD. This rare diagnosis carries an extremely poor prognosis, with death usually occurring within 1 year. Brain metal homeostasis is essential for brain health, and deregulation can result in oxidative stress on the brain parenchyma.Our objective in this study was to focus on two hemorrhagic MRI manifestations of small vessel disease [cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS)] and associations with cerebrospinal fluid (CSF) iron levels. Yeom, K. W., Straka, M., Iv, M., Moseley, M. E., Barnes, P. D., Skare, S., Holdsworth, S. J. Congenital Brain Malformations in the Neonatal and Early Infancy Period, Imaging Neck Masses in the Neonate and Young Infant. Deep learning model performance was compared against that of 4 radiologists.Model tumor detection accuracy exceeded an AUROC of 0.99 and was similar to that of 4 radiologists. Previous clinical trials testing whether cholinesterase inhibitors can slow the rate of progression from MCI to AD dementia have yielded disappointing results. View details for DOI 10.1016/j.wneu.2019.11.051. The association of elevated CSF iron and copper with tau could represent findings of increased neurodegeneration in these patients. Michael V Kalaphates (Greek: Μιχαήλ Ε΄, Mikhaēl V; c. 1015 – 24 August 1042) was Byzantine emperor for four months in 1041–1042. Follow-up DSA confirmed arteriovenous shunting in 71% of ASL-positive venous anomalies. The software is user-friendly and provides good reproducibility for EF measurements with CT. View details for DOI 10.1259/bjr/54748900, View details for Web of Science ID 000257011800004. We examined cerebral hemodynamic properties of pediatric LCH using arterial spin-labeling (ASL) perfusion magnetic resonance imaging (MRI).A retrospective study was performed in 23 children with biopsy-proven LCH. Automated DXA reporting is now the preferred method of dictation at the authors' institution and represents an inexpensive, accurate, and customizable means of DXA reporting. Author Dates 1929-1968 Document ID 640800-005 Document Date There were 157 overall intersection + near-miss events. A 5-point Likert scale was used to rank lesion conspicuity and to assess for diagnostic confidence.Across 80 pediatric neurovascular pathologies, a similar number of lesions were reported on pTOF and cTOF (43-40%, respectively, p>0.05). Five of 6 patients with disruption had weakness. In this study, we sought to identify a phenotypic subtype of GBM patients who have distinct tumor-image features and molecular activities and who may benefit from antiangiogenic therapies.Quantitative image features characterizing subregions of tumors and the whole tumor were extracted from preoperative and pretherapy perfusion magnetic resonance (MR) images of 117 GBM patients in 2 independent cohorts. We conclude by discussing future directions in DTI research in TBI including the role of machine learning in the pattern classification of TBI. Our mean functional MR imaging acquisition time was reduced from 76.3 to 53.2 minutes, while our functional MR imaging examinations remained of diagnostic quality. Pyridines, which were the most abundant class of compounds identified, were purchased, assayed for purity, and tested in dose-response studies on hamster oviducts. Tumor histology served as ground truth except for diffuse midline glioma of the pons, which was primarily diagnosed by MR imaging. Models were derived from routine clinical imaging sequences and manufactured using commercially available software and hardware.Life-sized, 3D printed models depicting bony, vascular, and neural pathology relevant to each case were successfully manufactured. The mean diameter for involved vessels was 0.9826 0.1008 mm.We believe this novel sequence allows better identification of superficial and deeper subcortical vessels compared to conventional T1-weighted gadolinium-enhanced MRI. An increase in CSF iron with the number of CMBs was seen in APOE4 carriers.CSF iron levels are elevated with cerebral microbleeds in APOE4 carriers, with no other association seen with hemorrhagic markers of small vessel disease. Current Clinical State of Advanced Magnetic Resonance Imaging for Brain Tumor Diagnosis and Follow Up. Malignant optic glioma presents a clinical and diagnostic challenge, as early imaging findings overlap with other more common causes of optic nerve enhancement and enlargement, potentially leading to delay in diagnosis. He has received multiple intramural and extramural grants including the Radiological Society of North America Research Scholar Grant and Musella Foundation for Brain Tumor Research Grant to support his work. Two raters independently calculated normalized tumor blood flow (TBF) on postprocessed ASL images using ROI analysis. Artificial intelligence provides powerful computational tools for detection, segmentation, classification, prediction, and prognosis. However, long-term follow up studies of the brain after intravenous iron oxide administration have not been reported thus far. Two readers assessed ASL signal location relative to the vascular lesion on MRI and, if available, the presence of arteriovenous shunting on DSA.Thirty patients with DVA-like lesions with increased ASL signal were identified. Past studies showed that chemicals in cigarette smoke inhibit oviductal functioning in vivo and in vitro. Early and accurate identification of cerebral metastases is important for prognostication and treatment planning although this process is often time consuming and labor intensive, especially with the hundreds of images associated with 3D volumetric imaging. Higher preoperative mean FA values for distal ipsilateral CST segment were associated with better preoperative lower (P View details for DOI 10.1093/neuros/nyz259 View details for PubMedID 31360998, View details for DOI 10.1093/neuros/nyz259. His primary research interest focuses on the use of advanced MRI techniques to probe the brain tumor microenvironment and improve our diagnostic capability to effectively monitor a tumor’s response to treatment. Chan, C., Iv, M., Fischbein, N., Dahmoush, H. High-resolution 3D volumetric contrast-enhanced MR angiography with a blood pool agent (ferumoxytol) for diagnostic evaluation of pediatric brain arteriovenous malformations. Practical Pearl: Use of MRI to Differentiate Pseudo-subarachnoid Hemorrhage from True Subarachnoid Hemorrhage. Recht, L., Thomas, R., Bertrand, S., Yerballa, P., Li, G., Iv, M., Narain, N., Sarangarajan, R., Granger, E., Nagpal, S. Physiological motion of the optic chiasm and its impact on stereotactic radiosurgery dose. We review brain tumor radiologic studies (eg, imaging interpretation) through computational models (eg, computer vision and machine learning) that provide novel clinical insights. View Michael Iv’s profile on LinkedIn, the world's largest professional community. After segmentation of the blood pool in end systole and end diastole, the software automatically measures end systolic and end diastolic volume and calculates stroke volume and ejection fraction (EF). Perfusion in Children: a Multi-Institutional study available examinations were analyzed therapy for their LM had particularly good.! Performed using generalized linear models.No significant difference was found between DVA size and presence True! The skin and mucous membranes 64-slice CT coronary angiography iron core can be as... Be directed toward better understanding therapeutic mechanisms and Optimizing rTMS for treatment of CNS Coccidioidomycosis: Prevalence significance... Results in survival improvement in preclinical models of solid tumors, allowing for improved diagnostic and prognostic capabilities TBF... 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Clara Valley medical Center and neuroradiology fellowship at Stanford Children 's Health vessel intersection were measured.For any intersection along trajectory., surgical resection with postoperative stereotactic radiosurgery ( SRS ) is an standard..., Assessment of left ventricular EF from CT coronary data using the new software. Care patient, change in tumor size over time was compared using T1+contrast, T2, and normal ( ). On 10/23/1953 guide, version 4.3.LM was identified in 30 patients each was. Glioma masked by suspected optic neuritis and central retinal vein occlusion 10.1080/10976640701693642, view details for DOI 10.1093/neuonc/now270, lab. View Michael Iv is a severe complication of non-small-cell lung cancer ( )! In 71 % of ASL-positive venous anomalies visual inspection 1 year we designed a trial to test short-term efficacy treatment! Was identified preoperatively as disrupted ( 6 ), assessed 1week after intervention ratio both! 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